Positive selection in admixed populations from Ethiopia
نویسندگان
چکیده
منابع مشابه
Genomic selection in admixed and crossbred populations.
In livestock, genomic selection (GS) has primarily been investigated by simulation of purebred populations. Traits of interest are, however, often measured in crossbred or mixed populations with uncertain breed composition. If such data are used as the training data for GS without accounting for breed composition, estimates of marker effects may be biased due to population stratification and ad...
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Genome-wide association studies (GWASs) are commonly used for the mapping of genetic loci that influence complex traits. A problem that is often encountered in both population-based and family-based GWASs is that of identifying cryptic relatedness and population stratification because it is well known that failure to appropriately account for both pedigree and population structure can lead to s...
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Large-scale genotyping of SNPs has shown a great promise in identifying markers that could be linked to diseases. One of the major obstacles involved in performing these studies is that the underlying population substructure could produce spurious associations. Population substructure can be caused by the presence of two distinct subpopulations or a single pool of admixed individuals. In this w...
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Genetic association studies have during the last decade proven to be a powerful approach to identifying disease-causing variants. However, many populations, like the Greenlandic Inuit population, have recently experienced substantial admixture with other populations, which can complicate association studies. One important complication is that most current methods for performing association test...
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Admixed populations arise when two or more previously isolated populations interbreed. Mapping asthma susceptibility loci in an admixed population using admixture mapping (AM) involves screening the genome of individuals of mixed ancestry for chromosomal regions that have a higher frequency of alleles from a parental population with higher asthma risk as compared with parental population with l...
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ژورنال
عنوان ژورنال: BMC Genetics
سال: 2020
ISSN: 1471-2156
DOI: 10.1186/s12863-020-00908-5